A case of Wegener's granulomatosis (WG) presenting with hearing loss and right facial nerve palsy is reported. The definitive diagnosis was based upon clinical data and serum cANCA and AECA detection. Early assessment of WG prevented surgical facial nerve decompression to treat a chronic otitis media complication. Immunosuppressive therapy with steroids, cyclophosphamide and methotrexate was required for relief of clinical symptoms and cANCA negativity as an expression of disease remission. The effectiveness of co-trimoxazole for preventing relapses of WG is discussed.
Cadoni, G., Agostino, S. E., Manna, R., Galli, J., 1/5, Early diagnosis and stage adapted treatment of Wegener's granulomatosis, <<JOURNAL OF LARYNGOLOGY AND OTOLOGY>>, 2003; 2003 (117): 208-211. [doi:10.1258/002221503321192539] [http://hdl.handle.net/10807/192201]
Early diagnosis and stage adapted treatment of Wegener's granulomatosis
Cadoni, Gabriella;Manna, Raffaele;Galli, Jacopo;
2003
Abstract
A case of Wegener's granulomatosis (WG) presenting with hearing loss and right facial nerve palsy is reported. The definitive diagnosis was based upon clinical data and serum cANCA and AECA detection. Early assessment of WG prevented surgical facial nerve decompression to treat a chronic otitis media complication. Immunosuppressive therapy with steroids, cyclophosphamide and methotrexate was required for relief of clinical symptoms and cANCA negativity as an expression of disease remission. The effectiveness of co-trimoxazole for preventing relapses of WG is discussed.
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