A defect of CD4(+) regulatory T cells (Treg) seems to be involved in the pathogenesis of multiple sclerosis (MS). Besides Treg, CD8(+) T cells also can suppress the immune response. Forkhead box p3 (Foxp3) is known to program the acquisition of suppressive capacities in CD4(+) T cells and recent studies showed that in vitro antigen activation leads to Foxp3 expression in CD8(+) T cells, gaining of suppressive activity. By flow cytometry we found a lower percentage of circulating CD8(+)Foxp3(+) T cells in relapsing than in remitting patients with MS and in controls. No significant differences were observed in CD8(+)Foxp3(+) T cell percentage between healthy subjects and patients in remission. Our data suggest that peripheral CD8(+)Foxp3(+) T cells may play a role in the maintenance of tolerance in MS.

Frisullo, G., Nociti, V., Iorio, R., Plantone, D., Patanella, A. K., Batocchi, A. P., CD8(+)Foxp3(+) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients, <<HUMAN IMMUNOLOGY>>, 2010; 2010 (Maggio): 437-441 [http://hdl.handle.net/10807/19196]

CD8(+)Foxp3(+) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients

Frisullo, Giovanni;Nociti, Viviana;Iorio, Raffaele;Plantone, Domenico;Patanella, Agata Katia;Batocchi, Anna Paola
2010

Abstract

A defect of CD4(+) regulatory T cells (Treg) seems to be involved in the pathogenesis of multiple sclerosis (MS). Besides Treg, CD8(+) T cells also can suppress the immune response. Forkhead box p3 (Foxp3) is known to program the acquisition of suppressive capacities in CD4(+) T cells and recent studies showed that in vitro antigen activation leads to Foxp3 expression in CD8(+) T cells, gaining of suppressive activity. By flow cytometry we found a lower percentage of circulating CD8(+)Foxp3(+) T cells in relapsing than in remitting patients with MS and in controls. No significant differences were observed in CD8(+)Foxp3(+) T cell percentage between healthy subjects and patients in remission. Our data suggest that peripheral CD8(+)Foxp3(+) T cells may play a role in the maintenance of tolerance in MS.
Inglese
Frisullo, G., Nociti, V., Iorio, R., Plantone, D., Patanella, A. K., Batocchi, A. P., CD8(+)Foxp3(+) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients, <>, 2010; 2010 (Maggio): 437-441 [http://hdl.handle.net/10807/19196]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/19196
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