Regulatory CD4+ CD25+Foxp3+ T cells are involved in the regulation of immune response and inhibit protective antitumor immunity. Celiac disease (CD), a food gluten-sensitive enteropathy, is considered a T-cell-mediated autoimmune disease and is generally associated with an overall increased risk of cancer in CD patients. We observed a higher percentage of circulating CD4+CD25+Foxp3+ T cells and an increased Foxp3 expression in CD4+CD25+ T cells from untreated than from treated CD patients. In co-culture, CD4+CD25+ T cells from both treated and untreated CD patients significantly suppressed the proliferation of autologous CD4+CD25(-) T cells similarly to values in healthy subjects. Our study suggests that Treg proportion and Foxp3 expression in circulating CD4+CD25+ T cells could justify the increased global risk of malignancy in CD population and support the efficacy of lifelong gluten-free diet in the reduction of the cancer risk.

Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Bianco, A., Plantone, D., Cammarota, G., Batocchi, A. P., Increased CD4(+)CD25(+)Foxp3(+) T Cells in Peripheral Blood of Celiac Disease Patients: Correlation with Dietary Treatment., <<HUMAN IMMUNOLOGY>>, 2009; 2009 (Giugno): 430-435 [http://hdl.handle.net/10807/19193]

Increased CD4(+)CD25(+)Foxp3(+) T Cells in Peripheral Blood of Celiac Disease Patients: Correlation with Dietary Treatment.

Frisullo, Giovanni;Nociti, Viviana;Iorio, Raffaele;Patanella, Agata Katia;Marti, Alessandro;Bianco, Assunta;Plantone, Domenico;Cammarota, Giovanni;Batocchi, Anna Paola
2009

Abstract

Regulatory CD4+ CD25+Foxp3+ T cells are involved in the regulation of immune response and inhibit protective antitumor immunity. Celiac disease (CD), a food gluten-sensitive enteropathy, is considered a T-cell-mediated autoimmune disease and is generally associated with an overall increased risk of cancer in CD patients. We observed a higher percentage of circulating CD4+CD25+Foxp3+ T cells and an increased Foxp3 expression in CD4+CD25+ T cells from untreated than from treated CD patients. In co-culture, CD4+CD25+ T cells from both treated and untreated CD patients significantly suppressed the proliferation of autologous CD4+CD25(-) T cells similarly to values in healthy subjects. Our study suggests that Treg proportion and Foxp3 expression in circulating CD4+CD25+ T cells could justify the increased global risk of malignancy in CD population and support the efficacy of lifelong gluten-free diet in the reduction of the cancer risk.
2009
Inglese
Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Bianco, A., Plantone, D., Cammarota, G., Batocchi, A. P., Increased CD4(+)CD25(+)Foxp3(+) T Cells in Peripheral Blood of Celiac Disease Patients: Correlation with Dietary Treatment., <<HUMAN IMMUNOLOGY>>, 2009; 2009 (Giugno): 430-435 [http://hdl.handle.net/10807/19193]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/19193
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