Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.

Rinninella, E., Mele, M. C., Raoul, P., Cintoni, M., Gasbarrini, A., Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system, <<BIOFACTORS>>, 2021; (N/A): 1-9. [doi:10.1002/biof.1786] [http://hdl.handle.net/10807/191506]

Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system

Rinninella E.;Mele M. C.;Raoul P.;Gasbarrini A.
2021

Abstract

Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.
Inglese
Rinninella, E., Mele, M. C., Raoul, P., Cintoni, M., Gasbarrini, A., Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system, <>, 2021; (N/A): 1-9. [doi:10.1002/biof.1786] [http://hdl.handle.net/10807/191506]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/191506
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