Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange transfusion. No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected.
Segni, G., Polidori, G., Romagnoli, C., Bucolome in prevention of hyperbilirubinaemia in preterm infants, <<ARCHIVES OF DISEASE IN CHILDHOOD>>, 1977; 52 (7): 549-550. [doi:10.1136/adc.52.7.549] [http://hdl.handle.net/10807/19010]
Bucolome in prevention of hyperbilirubinaemia in preterm infants
Segni, Giuseppe;Polidori, Giancarlo;Romagnoli, Costantino
1977
Abstract
Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange transfusion. No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected.
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