Acromegaly, caused in most cases by Growth Hormone (GH)-secreting pituitary adenomas, is characterized by increased skeletal growth and enlargement of the soft tissue, because GH and its effector Insulin-like Growth factor-1 are important regulators of bone homeostasis and have a central role in the longitudinal bone growth and maintenance of bone mass. Areas covered: Despite the anabolic effect of these hormones is well known, as a result of the stimulation of bone turnover and especially of bone formation, many acromegalic patients are suffering from a form of secondary osteoporosis with increased risk of fractures. Expert commentary: In this review, we summarize the pathophysiology, diagnosis, clinical picture, disease course and management of skeletal complications of acromegaly, focusing in particular on secondary osteoporosis and fracture risk in acromegaly.

Bima, C., Chiloiro, S., Mormando, M., Piacentini, S., Bracaccia, E., Giampietro, A., Tartaglione, L., Bianchi, A., De Marinis Grasso, L., Understanding the effect of acromegaly on the human skeleton., <<EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM>>, 2016; (11): 263-270. [doi:10.1080/17446651.2016.1179108] [http://hdl.handle.net/10807/188443]

Understanding the effect of acromegaly on the human skeleton.

Chiloiro, Sabrina;Piacentini, Serena;Giampietro, Antonella;Tartaglione, Linda;Bianchi, Antonio;De Marinis Grasso, Laura
2016

Abstract

Acromegaly, caused in most cases by Growth Hormone (GH)-secreting pituitary adenomas, is characterized by increased skeletal growth and enlargement of the soft tissue, because GH and its effector Insulin-like Growth factor-1 are important regulators of bone homeostasis and have a central role in the longitudinal bone growth and maintenance of bone mass. Areas covered: Despite the anabolic effect of these hormones is well known, as a result of the stimulation of bone turnover and especially of bone formation, many acromegalic patients are suffering from a form of secondary osteoporosis with increased risk of fractures. Expert commentary: In this review, we summarize the pathophysiology, diagnosis, clinical picture, disease course and management of skeletal complications of acromegaly, focusing in particular on secondary osteoporosis and fracture risk in acromegaly.
2016
Inglese
Bima, C., Chiloiro, S., Mormando, M., Piacentini, S., Bracaccia, E., Giampietro, A., Tartaglione, L., Bianchi, A., De Marinis Grasso, L., Understanding the effect of acromegaly on the human skeleton., <<EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM>>, 2016; (11): 263-270. [doi:10.1080/17446651.2016.1179108] [http://hdl.handle.net/10807/188443]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/188443
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