The immunomodulatory properties of interferon may concur to precipitate or worsen an underlying autoimmune disorders. We report the cases of two men who displayed the various features of coeliac disease during a treatment with 4-interferon (in one case associated with ribavirin) for chronic hepatitis C. The patients stopped the interferon treatment and the symptoms and histological disorders improved after a gluten-free diet. Alpha-interferon is available worldwide for treatment of chronic viral hepatitis. Before treatment with this drug, the patients would have to be monitored for coeliac disease.
Cammarota, G., Cuoco, L., Cianci, R., Pandolfi, F., Gasbarrini, G. B., Onset of coeliac disease during treatment with interferon for chronic hepatitis C., <<THE LANCET>>, 2000; 356 (9240): 1494-1495. [doi:10.1016/S0140-6736(00)02880-4] [http://hdl.handle.net/10807/187115]
Onset of coeliac disease during treatment with interferon for chronic hepatitis C.
Cammarota, Giovanni;Cianci, Rossella;Pandolfi, Franco;Gasbarrini, Giovanni Battista
2000
Abstract
The immunomodulatory properties of interferon may concur to precipitate or worsen an underlying autoimmune disorders. We report the cases of two men who displayed the various features of coeliac disease during a treatment with 4-interferon (in one case associated with ribavirin) for chronic hepatitis C. The patients stopped the interferon treatment and the symptoms and histological disorders improved after a gluten-free diet. Alpha-interferon is available worldwide for treatment of chronic viral hepatitis. Before treatment with this drug, the patients would have to be monitored for coeliac disease.
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