BACKGROUND: A sizeable number of patients with a diagnosis of non-ST segment elevation acute coronary syndrome show non-obstructive coronary artery disease. In this study we assessed whether differences in vascular and cardiac autonomic function exist between non-ST segment elevation acute coronary syndrome patients with obstructive or non-obstructive coronary artery disease.METHODS AND RESULTS: Systemic endothelium-dependent and independent vascular dilator function (assessed by flow-mediated dilation and nitrate-mediated dilation of the brachial artery, respectively) and cardiac autonomic function (assessed by time-domain and frequency-domain heart rate variability parameters) were assessed on admission in 120 patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Patients were divided into two groups according to coronary angiography findings: (a) 59 (49.2%) with obstructive coronary artery disease (≥50% stenosis in any epicardial arteries); (b) 61 (50.8%) with non-obstructive coronary artery disease. No significant differences between the two groups were found in both flow-mediated dilation (5.03±2.6 vs. 5.40±2.5%, respectively; P=0.37) and nitrate-mediated dilatation (6.79±2.8 vs. 7.30±3.4%, respectively; P=0.37). No significant differences were also observed between the two groups both in time-domain and frequency-domain heart rate variability variables, although the triangular index tended to be lower in obstructive coronary artery disease patients (30.2±9.5 vs. 33.9±11.6, respectively; P=0.058). Neither vascular nor heart rate variability variables predicted the recurrence of angina, requiring emergency room admission or re-hospitalisation, during 11.3 months of follow-up.CONCLUSIONS: Among patients admitted with a diagnosis of non-ST segment elevation acute coronary syndrome we found no significant differences in systemic vascular dilator function and cardiac autonomic function between those with obstructive coronary artery disease and those with non-obstructive coronary artery disease.

Lanza, G. A., Ruscio, E., Ingrasciotta, G., Felici, T., Filice, M., De Vita, A., Tremamunno, S., Villano, A., Crea, F., Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome, <<EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE>>, 2021; 10 (2): 164-169. [doi:10.1177/2048872620918714] [http://hdl.handle.net/10807/178668]

Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome

Lanza, Gaetano Antonio;Ruscio, Eleonora;Ingrasciotta, Gessica;Felici, Tamara;Filice, Monica;De Vita, Antonio;Tremamunno, Saverio;Crea, Filippo
2020

Abstract

BACKGROUND: A sizeable number of patients with a diagnosis of non-ST segment elevation acute coronary syndrome show non-obstructive coronary artery disease. In this study we assessed whether differences in vascular and cardiac autonomic function exist between non-ST segment elevation acute coronary syndrome patients with obstructive or non-obstructive coronary artery disease.METHODS AND RESULTS: Systemic endothelium-dependent and independent vascular dilator function (assessed by flow-mediated dilation and nitrate-mediated dilation of the brachial artery, respectively) and cardiac autonomic function (assessed by time-domain and frequency-domain heart rate variability parameters) were assessed on admission in 120 patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Patients were divided into two groups according to coronary angiography findings: (a) 59 (49.2%) with obstructive coronary artery disease (≥50% stenosis in any epicardial arteries); (b) 61 (50.8%) with non-obstructive coronary artery disease. No significant differences between the two groups were found in both flow-mediated dilation (5.03±2.6 vs. 5.40±2.5%, respectively; P=0.37) and nitrate-mediated dilatation (6.79±2.8 vs. 7.30±3.4%, respectively; P=0.37). No significant differences were also observed between the two groups both in time-domain and frequency-domain heart rate variability variables, although the triangular index tended to be lower in obstructive coronary artery disease patients (30.2±9.5 vs. 33.9±11.6, respectively; P=0.058). Neither vascular nor heart rate variability variables predicted the recurrence of angina, requiring emergency room admission or re-hospitalisation, during 11.3 months of follow-up.CONCLUSIONS: Among patients admitted with a diagnosis of non-ST segment elevation acute coronary syndrome we found no significant differences in systemic vascular dilator function and cardiac autonomic function between those with obstructive coronary artery disease and those with non-obstructive coronary artery disease.
Inglese
Lanza, G. A., Ruscio, E., Ingrasciotta, G., Felici, T., Filice, M., De Vita, A., Tremamunno, S., Villano, A., Crea, F., Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome, <<EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE>>, 2021; 10 (2): 164-169. [doi:10.1177/2048872620918714] [http://hdl.handle.net/10807/178668]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/178668
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