Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential.
Santoro, A., Angelico, G., Fiorentino, V., Zhang, Q., Spadola, S., Carlino, A., Sanchez, A. M., Franceschini, G., Zannoni, G. F., Mule', A., Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature, <<DIAGNOSTICS>>, 2021; 11 (11 (4)): 709-709. [doi:10.3390/diagnostics11040709] [http://hdl.handle.net/10807/178081]
Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature
Santoro, Angela;Zhang, Qianqian;Carlino, Angela;Franceschini, Gianluca;Zannoni, Gian Franco;Mule', Antonino
2021
Abstract
Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential.
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