The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.
Biscetti, F., Rando, M. M., Nardella, E., Cecchini, A. L., Bruno, P., Landolfi, R., Flex, A., Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2020; 21 (21): 1-14. [doi:10.3390/ijms21218141] [http://hdl.handle.net/10807/177893]
Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury
Biscetti, Federico
Primo
;Nardella, Elisabetta;Cecchini, Andrea Leonardo;Bruno, Piergiorgio;Landolfi, RaffaelePenultimo
;Flex, AndreaUltimo
2020
Abstract
The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.
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