Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been profoundly revised following recent advances in the understanding of its pathophysiology. In the current model, a crosstalk between keratinocytes, neutrophils, mast cells, T cells, and dendritic cells is thought to create inflammatory and pro-proliferative circuits mediated by chemokines and cytokines. Various triggers, including recently identified autoantigens, Toll-like receptor agonists, chemerin, and thymic stromal lymphopoietin may activate the pathogenic cascade resulting in enhanced production of pro-inflammatory and proliferation-inducing mediators such as interleukin (IL)-17, tumor necrosis factor (TNF)-α, IL-23, IL-22, interferon (IFN)-α, and IFN-γ by immune cells. Among these key cytokines lie therapeutic targets for currently approved antipsoriatic therapies. This review aims to provide a comprehensive overview on the immune-mediated mechanisms characterizing the current pathogenic model of psoriasis.

Chiricozzi, A., Romanelli, P., Volpe, E., Borsellino, G., Romanelli, M., Scanning the immunopathogenesis of psoriasis, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2018; 19 (1): 179-N/A. [doi:10.3390/ijms19010179] [http://hdl.handle.net/10807/177172]

Scanning the immunopathogenesis of psoriasis

Chiricozzi, Andrea;
2018

Abstract

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been profoundly revised following recent advances in the understanding of its pathophysiology. In the current model, a crosstalk between keratinocytes, neutrophils, mast cells, T cells, and dendritic cells is thought to create inflammatory and pro-proliferative circuits mediated by chemokines and cytokines. Various triggers, including recently identified autoantigens, Toll-like receptor agonists, chemerin, and thymic stromal lymphopoietin may activate the pathogenic cascade resulting in enhanced production of pro-inflammatory and proliferation-inducing mediators such as interleukin (IL)-17, tumor necrosis factor (TNF)-α, IL-23, IL-22, interferon (IFN)-α, and IFN-γ by immune cells. Among these key cytokines lie therapeutic targets for currently approved antipsoriatic therapies. This review aims to provide a comprehensive overview on the immune-mediated mechanisms characterizing the current pathogenic model of psoriasis.
2018
Inglese
Chiricozzi, A., Romanelli, P., Volpe, E., Borsellino, G., Romanelli, M., Scanning the immunopathogenesis of psoriasis, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2018; 19 (1): 179-N/A. [doi:10.3390/ijms19010179] [http://hdl.handle.net/10807/177172]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/177172
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