Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up‐to‐date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell‐based approaches.

Tiberio, F., Cacciotti, I., Frassanito, P., Nocca, G., Tamburrini, G., Arcovito, A., Lattanzi, W., Personalized bone reconstruction and regeneration in the treatment of craniosynostosis, <<APPLIED SCIENCES>>, 2021; 11 (6): 2649-N/A. [doi:10.3390/app11062649] [http://hdl.handle.net/10807/177111]

Personalized bone reconstruction and regeneration in the treatment of craniosynostosis

Tiberio, F.
Primo
;
Frassanito, P.;Nocca, G.;Tamburrini, G.;Arcovito, A.
Penultimo
;
Lattanzi, W.
Ultimo
2021

Abstract

Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up‐to‐date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell‐based approaches.
Inglese
Tiberio, F., Cacciotti, I., Frassanito, P., Nocca, G., Tamburrini, G., Arcovito, A., Lattanzi, W., Personalized bone reconstruction and regeneration in the treatment of craniosynostosis, <<APPLIED SCIENCES>>, 2021; 11 (6): 2649-N/A. [doi:10.3390/app11062649] [http://hdl.handle.net/10807/177111]
File in questo prodotto:
File Dimensione Formato  
2021_APPL SCI_Personalized Bone Reconstruction and Regeneration in the.pdf

accesso aperto

Descrizione: File accessibile al download open access
Tipologia file ?: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 1.15 MB
Formato Adobe PDF
1.15 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/177111
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact