The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.

Di Sante, G., Tredicine, M., Rolla, S., Di Pino, A., Ria, F., Past and future of the molecular characterization of the T cell repertoire: Some highlights of eli sercarz’s contributions, <<CRITICAL REVIEWS IN IMMUNOLOGY>>, 2021; 40 (3): 249-253. [doi:10.1615/CritRevImmunol.2020034613] [http://hdl.handle.net/10807/174976]

Past and future of the molecular characterization of the T cell repertoire: Some highlights of eli sercarz’s contributions

Di Sante, G.
;
Tredicine, M.;Di Pino, A.;Ria, F.
2020

Abstract

The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.
Inglese
Di Sante, G., Tredicine, M., Rolla, S., Di Pino, A., Ria, F., Past and future of the molecular characterization of the T cell repertoire: Some highlights of eli sercarz’s contributions, <<CRITICAL REVIEWS IN IMMUNOLOGY>>, 2021; 40 (3): 249-253. [doi:10.1615/CritRevImmunol.2020034613] [http://hdl.handle.net/10807/174976]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/174976
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact