For decades, we have known from autopsy observations that the proximate cause of the majority of acute coronary syndromes ( ACS) is occlusive thrombosis generated by plaque rupture or, less frequently, superficial erosion. Patients with ACS caused by plaque erosion seem to have a better long-term prognosis compared to those with plaque rupture, and may be stabilized by dual antiplatelet therapy without the need for stenting in a non-trivial proportion of cases, limiting the expenses and potential complications of invasive procedures. The accurate prediction of plaque erosion and the identification of specific biomarkers that could be used at the point-of-care without the need of invasive imaging would take us a step closer to the holy grail of precision medicine in patients with ACS.

Vergallo, R., Jang, I. -., Crea, F., New prediction tools and treatment for ACS patients with plaque erosion, <<ATHEROSCLEROSIS>>, 2021; (318): 45-51. [doi:10.1016/j.atherosclerosis.2020.10.016] [http://hdl.handle.net/10807/174387]

New prediction tools and treatment for ACS patients with plaque erosion

Vergallo, Rocco;Crea, Filippo
2021

Abstract

For decades, we have known from autopsy observations that the proximate cause of the majority of acute coronary syndromes ( ACS) is occlusive thrombosis generated by plaque rupture or, less frequently, superficial erosion. Patients with ACS caused by plaque erosion seem to have a better long-term prognosis compared to those with plaque rupture, and may be stabilized by dual antiplatelet therapy without the need for stenting in a non-trivial proportion of cases, limiting the expenses and potential complications of invasive procedures. The accurate prediction of plaque erosion and the identification of specific biomarkers that could be used at the point-of-care without the need of invasive imaging would take us a step closer to the holy grail of precision medicine in patients with ACS.
2021
Inglese
Vergallo, R., Jang, I. -., Crea, F., New prediction tools and treatment for ACS patients with plaque erosion, <<ATHEROSCLEROSIS>>, 2021; (318): 45-51. [doi:10.1016/j.atherosclerosis.2020.10.016] [http://hdl.handle.net/10807/174387]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/174387
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 11
social impact