Magnetic resonance imaging is the most used technique of neuroimaging. Using recent advances in magnetic resonance application it is possible to investigate several changes in neurodegenerative disease. Among different techniques, magnetization-transfer imaging (MTI), a magnetic resonance acquisition protocol assessing the magnetization exchange between protons bound to water and those bound to macromolecules, is able to identify microstructural brain tissue changes peculiar of neurodegenerative diseases. This review provides a report on the MTI technique and its use in the dementia disorders, Huntington's disease and parkinsonisms, comprehensive of the predictive values of MTI in the identification of early-phase disease.
Tambasco, N., Nigro, P., Romoli, M., Simoni, S., Parnetti, L., Calabresi, P., Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism, <<JOURNAL OF THE NEUROLOGICAL SCIENCES>>, 2015; 353 (1-2): 1-8. [doi:10.1016/j.jns.2015.03.025] [http://hdl.handle.net/10807/173353]
Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism
Calabresi, P.
2015
Abstract
Magnetic resonance imaging is the most used technique of neuroimaging. Using recent advances in magnetic resonance application it is possible to investigate several changes in neurodegenerative disease. Among different techniques, magnetization-transfer imaging (MTI), a magnetic resonance acquisition protocol assessing the magnetization exchange between protons bound to water and those bound to macromolecules, is able to identify microstructural brain tissue changes peculiar of neurodegenerative diseases. This review provides a report on the MTI technique and its use in the dementia disorders, Huntington's disease and parkinsonisms, comprehensive of the predictive values of MTI in the identification of early-phase disease.
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