Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.

Monticelli, M., Zeppa, P., Zenga, F., Altieri, R., Mammi, M., Bertero, L., Castellano, I., Cassoni, P., Melcarne, A., La Rocca, G., Sabatino, G., Ducati, A., Garbossa, D., The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review, <<CLINICAL NEUROLOGY AND NEUROSURGERY>>, 2018; 170 (n.d): 120-126. [doi:10.1016/j.clineuro.2018.05.015] [http://hdl.handle.net/10807/172248]

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

La Rocca, G;Sabatino, G;
2018

Abstract

Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.
Inglese
Monticelli, M., Zeppa, P., Zenga, F., Altieri, R., Mammi, M., Bertero, L., Castellano, I., Cassoni, P., Melcarne, A., La Rocca, G., Sabatino, G., Ducati, A., Garbossa, D., The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review, <>, 2018; 170 (n.d): 120-126. [doi:10.1016/j.clineuro.2018.05.015] [http://hdl.handle.net/10807/172248]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/172248
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