1. Monotherapy with mitotane is recommended in patients after incomplete surgical resection or in patients not fit for surgery or chemotherapy 1 ⊕⊕OO. 2. Monotherapy with mitotane may be recommended in advanced ACC with involvement of few organs and low-grade mitotic index, particularly when RFS after removal of the primary tumor has been longer than 12 months 1 ⊕OOOO. 3. The chemotherapeutic regimen EDP in combination with mitotane is recommended in most patients with advanced or metastatic ACC 1 ⊕⊕⊕⊕. 4. There are insufficient data to recommend a particular targeted therapy in patients with advanced ACC beyond ongoing clinical trials.
Stigliano, A., Chiodini, I., Giordano, R., Faggiano, A., Canu, L., Della Casa, S., Loli, P., Luconi, M., Mantero, F., Terzolo, M., Management of adrenocortical carcinoma: A consensus statement of the Italian Society of Endocrinology (SIE), <<JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION>>, 2016; 39 (1): 103-121. [doi:10.1007/s40618-015-0349-9] [http://hdl.handle.net/10807/172173]
Management of adrenocortical carcinoma: A consensus statement of the Italian Society of Endocrinology (SIE)
L.; Della Casa;
2016
Abstract
1. Monotherapy with mitotane is recommended in patients after incomplete surgical resection or in patients not fit for surgery or chemotherapy 1 ⊕⊕OO. 2. Monotherapy with mitotane may be recommended in advanced ACC with involvement of few organs and low-grade mitotic index, particularly when RFS after removal of the primary tumor has been longer than 12 months 1 ⊕OOOO. 3. The chemotherapeutic regimen EDP in combination with mitotane is recommended in most patients with advanced or metastatic ACC 1 ⊕⊕⊕⊕. 4. There are insufficient data to recommend a particular targeted therapy in patients with advanced ACC beyond ongoing clinical trials.
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