Four pregnant women with antithrombin III congenital deficiency underwent thrombosis prophylaxis including oral anticoagulants administered from the 16-18th week to the 36-37th week of pregnancy, subcutaneous heparin before the 16-18th week and after the 36-37th week, and a single infusion of AT III concentrate in the peripartum period in order to obtain a minimal level of 0.8 U/ml of AT III functional activity. The level of circulating AT III after the concentrate infusion needs to be evaluated by functional methods, because of a consistent amount in the concentrates of inactive AT III immunoreactive material. No thrombotic or haemorrhagic complication occurred after starting prophylaxis in any woman either in any newborn.

De Stefano, V., Leone, M. G., De Carolis, S., Ferrelli, R., Di Donfrancesco, A., Moneta, E., Bizzi, B., Management of pregnancy in women with antithrombin III congenital defect: Report of four cases, <<THROMBOSIS AND HAEMOSTASIS>>, 1988; 59 (2): 193-196. [doi:10.1055/s-0038-1642752] [http://hdl.handle.net/10807/171914]

Management of pregnancy in women with antithrombin III congenital defect: Report of four cases

De Stefano, Valerio;Leone, Maria Grazia;De Carolis, Sara;
1988

Abstract

Four pregnant women with antithrombin III congenital deficiency underwent thrombosis prophylaxis including oral anticoagulants administered from the 16-18th week to the 36-37th week of pregnancy, subcutaneous heparin before the 16-18th week and after the 36-37th week, and a single infusion of AT III concentrate in the peripartum period in order to obtain a minimal level of 0.8 U/ml of AT III functional activity. The level of circulating AT III after the concentrate infusion needs to be evaluated by functional methods, because of a consistent amount in the concentrates of inactive AT III immunoreactive material. No thrombotic or haemorrhagic complication occurred after starting prophylaxis in any woman either in any newborn.
1988
Inglese
De Stefano, V., Leone, M. G., De Carolis, S., Ferrelli, R., Di Donfrancesco, A., Moneta, E., Bizzi, B., Management of pregnancy in women with antithrombin III congenital defect: Report of four cases, <<THROMBOSIS AND HAEMOSTASIS>>, 1988; 59 (2): 193-196. [doi:10.1055/s-0038-1642752] [http://hdl.handle.net/10807/171914]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/171914
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 44
  • ???jsp.display-item.citation.isi??? ND
social impact