Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the "BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons" (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

Calvani, R., Federico Marini, A. P., Biancolillo Jacopo Gervasoni, A., Persichilli, S., Primiano, A., José Coelho-Junior, H., Bossola, M., Urbani, A., Landi, F., Bernabei, R., Marzetti, E., A Distinct Pattern of Circulating Amino Acids Characterizes OlderPersons with Physical Frailty and Sarcopenia: Results from the BIOSPHEREStudy, <<NUTRIENTS>>, 2018; 10 (11): N/A-N/A. [doi:10.3390/nu10111691] [http://hdl.handle.net/10807/170810]

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Calvani, Riccardo;Persichilli, Silvia;Primiano, Aniello;Bossola, Maurizio;Urbani, Andrea;Landi, Francesco;Bernabei, Roberto;Marzetti, Emanuele
2018

Abstract

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the "BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons" (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.
2018
Inglese
Calvani, R., Federico Marini, A. P., Biancolillo Jacopo Gervasoni, A., Persichilli, S., Primiano, A., José Coelho-Junior, H., Bossola, M., Urbani, A., Landi, F., Bernabei, R., Marzetti, E., A Distinct Pattern of Circulating Amino Acids Characterizes OlderPersons with Physical Frailty and Sarcopenia: Results from the BIOSPHEREStudy, <<NUTRIENTS>>, 2018; 10 (11): N/A-N/A. [doi:10.3390/nu10111691] [http://hdl.handle.net/10807/170810]
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