Objectives: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. Methods: This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan-Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. Results: Of the 600 original patients, 531 (88.5%), mean age 67±10 years, mean disease duration 6.1±6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0-4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade ≥III vs

Conaghan, P. G., D'Agostino, M. A., Le Bars, M., Baron, G., Schmidely, N., Wakefield, R., Ravaud, P., Grassi, W., Martin-Mola, E., So, A., Backhaus, M., Malaise, M., Emery, P., Dougados, M., Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: Results from a large, 3-year, prospective EULAR study, <<ANNALS OF THE RHEUMATIC DISEASES>>, 2010; 69 (4): 644-647. [doi:10.1136/ard.2008.099564] [http://hdl.handle.net/10807/170252]

Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: Results from a large, 3-year, prospective EULAR study

D'Agostino, Maria Antonietta
Co-primo
Conceptualization
;
2010

Abstract

Objectives: To determine clinical and ultrasonographic predictors of joint replacement surgery across Europe in primary osteoarthritis (OA) of the knee. Methods: This was a 3-year prospective study of a painful OA knee cohort (from a EULAR-sponsored, multicentre study). All subjects had clinical evaluation, radiographs and ultrasonography (US) at study entry. The rate of knee replacement surgery over the 3-year follow-up period was determined using Kaplan-Meier survival data analyses. Predictive factors for joint replacement were identified by univariate log-rank test then multivariate analysis using a Cox proportional-hazards regression model. Potential baseline predictors included demographic, clinical, radiographic and US features. Results: Of the 600 original patients, 531 (88.5%), mean age 67±10 years, mean disease duration 6.1±6.9 years, had follow-up data and were analysed. During follow-up (median 3 years; range 0-4 years), knee replacement was done or required for 94 patients (estimated event rate of 17.7%). In the multivariate analysis, predictors of joint replacement were as follows: Kellgren and Lawrence radiographic grade (grade ≥III vs
2010
Inglese
Conaghan, P. G., D'Agostino, M. A., Le Bars, M., Baron, G., Schmidely, N., Wakefield, R., Ravaud, P., Grassi, W., Martin-Mola, E., So, A., Backhaus, M., Malaise, M., Emery, P., Dougados, M., Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: Results from a large, 3-year, prospective EULAR study, <<ANNALS OF THE RHEUMATIC DISEASES>>, 2010; 69 (4): 644-647. [doi:10.1136/ard.2008.099564] [http://hdl.handle.net/10807/170252]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/170252
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