Introduction: We ascertained whether plasma chromogranin A enhances the power of serology assessing prostate cancer (PC). Materials and Methods: We studied 56 PC and 83 benign prostatic hyperplasia (BPH) patients. In the sera we measured total prostate-specific antigen (tPSA) and free PSA (fPSA) and calculated the ratio between fPSA and tPSA (f/tPSA). In plasma samples the levels of chromogranin A (CgA) were also assayed. Results: PC patients had higher CgA (p < 0.005) and tPSA (p < 0.05) levels, and a lower f/tPSA ratio (p < 0.001), than BPH patients. When f/tPSA and CgA were combined, the diagnostic sensitivity was enhanced (57-73%), while the specificity had only an 8% reduction (from 89 to 80%). CgA was only correlated to the Gleason PC score (p < 0.05). Conclusions: CgA determination in PC may enhance the diagnostic accuracy of the f/tPSA assay and provides useful information on the tumor grade. Copyright © 2005 S. Karger AG.
Fracalanza, S., Prayer-Galetti, T., Pinto, F., Navaglia, F., Sacco, E., Ciaccia, M., Plebani, M., Pagano, F., Basso, D., Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen determination, <<UROLOGIA INTERNATIONALIS>>, 2005; 75 (1): 57-61. [doi:10.1159/000085929] [http://hdl.handle.net/10807/169443]
Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen determination
Pinto, Francesco;Sacco, Emilio;
2005
Abstract
Introduction: We ascertained whether plasma chromogranin A enhances the power of serology assessing prostate cancer (PC). Materials and Methods: We studied 56 PC and 83 benign prostatic hyperplasia (BPH) patients. In the sera we measured total prostate-specific antigen (tPSA) and free PSA (fPSA) and calculated the ratio between fPSA and tPSA (f/tPSA). In plasma samples the levels of chromogranin A (CgA) were also assayed. Results: PC patients had higher CgA (p < 0.005) and tPSA (p < 0.05) levels, and a lower f/tPSA ratio (p < 0.001), than BPH patients. When f/tPSA and CgA were combined, the diagnostic sensitivity was enhanced (57-73%), while the specificity had only an 8% reduction (from 89 to 80%). CgA was only correlated to the Gleason PC score (p < 0.05). Conclusions: CgA determination in PC may enhance the diagnostic accuracy of the f/tPSA assay and provides useful information on the tumor grade. Copyright © 2005 S. Karger AG.
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