At present, there is no standard of care on the use of letrozole in ovarian cancer management. We performed a systematic review of the available literature addressing this issue. Data demonstrated a role for letrozole in ovarian cancer, in both the primary and recurrent setting. Letrozole, which has a favorable toxicity profile, seems to assure a prolonged recurrence-free interval, particularly when used as maintenance treatment, in low grade serous ovarian cancer; in recurrent cases it had also led to prolonged disease control. However, the optimal setting and biologically relevant patient population needs to be defined in larger trials.

Marchetti, C., De Felice, F., Ergasti, R., Scambia, G., Fagotti, A., Letrozole in the management of advanced ovarian cancer: An old drug as a new targeted therapy, <<INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER>>, 2020; 30 (7): 1058-1064. [doi:10.1136/ijgc-2019-001128] [http://hdl.handle.net/10807/167489]

Letrozole in the management of advanced ovarian cancer: An old drug as a new targeted therapy

Marchetti, C.;Ergasti, R.;Scambia, G.;Fagotti, A.
2020

Abstract

At present, there is no standard of care on the use of letrozole in ovarian cancer management. We performed a systematic review of the available literature addressing this issue. Data demonstrated a role for letrozole in ovarian cancer, in both the primary and recurrent setting. Letrozole, which has a favorable toxicity profile, seems to assure a prolonged recurrence-free interval, particularly when used as maintenance treatment, in low grade serous ovarian cancer; in recurrent cases it had also led to prolonged disease control. However, the optimal setting and biologically relevant patient population needs to be defined in larger trials.
2020
Inglese
Marchetti, C., De Felice, F., Ergasti, R., Scambia, G., Fagotti, A., Letrozole in the management of advanced ovarian cancer: An old drug as a new targeted therapy, <<INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER>>, 2020; 30 (7): 1058-1064. [doi:10.1136/ijgc-2019-001128] [http://hdl.handle.net/10807/167489]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/167489
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