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EnglishBy the end of February 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raided Northern Italy causing an exponential increase of cases. Newonset smell and taste disorders (STD) are common findings in SARS-CoV-2 patients [2], whereas severe neurological symptoms are less commonly observed. The question has been raised whether mild neurological symptoms indicate a neuroinvasive potential of SARS-CoV-2. Ability to invade the central nervous system (CNS) through the olfactory neuroepithelium has been demonstrated for previous strains of coronavirus [3]. Furthermore, nasal epithelial cells display a high expression of the SARS-CoV-2 receptor, angiotensinconverting enzyme 2. CNS involvement is supported by the observation of MRI abnormalities in the olfactory bulb of some patients with SARS-CoV-2 infection and STD. We studied a cohort of SARS-CoV-2-infected patients with new-onset STD.
Cocco, A., Amami, P., Desai, A., Voza, A., Ferreli, F., Albanese, A., Neurological features in SARS-CoV-2-infected patients with smell and taste disorder, <<JOURNAL OF NEUROLOGY>>, 2020; (N/A): N/A-N/A. [doi:10.1007/s00415-020-10135-8] [http://hdl.handle.net/10807/167022]
| Autori: | ||
| Titolo: | Neurological features in SARS-CoV-2-infected patients with smell and taste disorder | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00415-020-10135-8 | |
| Data di pubblicazione: | 2020 | |
| Abstract: | By the end of February 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raided Northern Italy causing an exponential increase of cases. Newonset smell and taste disorders (STD) are common findings in SARS-CoV-2 patients [2], whereas severe neurological symptoms are less commonly observed. The question has been raised whether mild neurological symptoms indicate a neuroinvasive potential of SARS-CoV-2. Ability to invade the central nervous system (CNS) through the olfactory neuroepithelium has been demonstrated for previous strains of coronavirus [3]. Furthermore, nasal epithelial cells display a high expression of the SARS-CoV-2 receptor, angiotensinconverting enzyme 2. CNS involvement is supported by the observation of MRI abnormalities in the olfactory bulb of some patients with SARS-CoV-2 infection and STD. We studied a cohort of SARS-CoV-2-infected patients with new-onset STD. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Cocco, A., Amami, P., Desai, A., Voza, A., Ferreli, F., Albanese, A., Neurological features in SARS-CoV-2-infected patients with smell and taste disorder, <<JOURNAL OF NEUROLOGY>>, 2020; (N/A): N/A-N/A. [doi:10.1007/s00415-020-10135-8] [http://hdl.handle.net/10807/167022] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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