By the end of February 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raided Northern Italy causing an exponential increase of cases. Newonset smell and taste disorders (STD) are common findings in SARS-CoV-2 patients [2], whereas severe neurological symptoms are less commonly observed. The question has been raised whether mild neurological symptoms indicate a neuroinvasive potential of SARS-CoV-2. Ability to invade the central nervous system (CNS) through the olfactory neuroepithelium has been demonstrated for previous strains of coronavirus [3]. Furthermore, nasal epithelial cells display a high expression of the SARS-CoV-2 receptor, angiotensinconverting enzyme 2. CNS involvement is supported by the observation of MRI abnormalities in the olfactory bulb of some patients with SARS-CoV-2 infection and STD. We studied a cohort of SARS-CoV-2-infected patients with new-onset STD.

Cocco, A., Amami, P., Desai, A., Voza, A., Ferreli, F., Albanese, A., Neurological features in SARS-CoV-2-infected patients with smell and taste disorder, <<JOURNAL OF NEUROLOGY>>, 2020; (N/A): N/A-N/A. [doi:10.1007/s00415-020-10135-8] [http://hdl.handle.net/10807/167022]

Neurological features in SARS-CoV-2-infected patients with smell and taste disorder

Amami, Paolo;Albanese, Alberto
Primo
2020

Abstract

By the end of February 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raided Northern Italy causing an exponential increase of cases. Newonset smell and taste disorders (STD) are common findings in SARS-CoV-2 patients [2], whereas severe neurological symptoms are less commonly observed. The question has been raised whether mild neurological symptoms indicate a neuroinvasive potential of SARS-CoV-2. Ability to invade the central nervous system (CNS) through the olfactory neuroepithelium has been demonstrated for previous strains of coronavirus [3]. Furthermore, nasal epithelial cells display a high expression of the SARS-CoV-2 receptor, angiotensinconverting enzyme 2. CNS involvement is supported by the observation of MRI abnormalities in the olfactory bulb of some patients with SARS-CoV-2 infection and STD. We studied a cohort of SARS-CoV-2-infected patients with new-onset STD.
2020
Inglese
Cocco, A., Amami, P., Desai, A., Voza, A., Ferreli, F., Albanese, A., Neurological features in SARS-CoV-2-infected patients with smell and taste disorder, <<JOURNAL OF NEUROLOGY>>, 2020; (N/A): N/A-N/A. [doi:10.1007/s00415-020-10135-8] [http://hdl.handle.net/10807/167022]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/167022
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 25
social impact