The goal of supporting and directing tissue regeneration requires the design of new, advanced materials, with features like biocompatibility, biodegradability and adequate mechanical properties. Our work was focused on developing a new injectable biomimetic composite material, based on a peptidic hydrogel and calcium phosphates with the aim of mimicking the chemical composition of natural bone tissue. Arg-Gly-Asp-grafted chitosan was used to promote cell adhesion. The obtained composite hydrogel was characterized with differential scanning calorimetry measurements, rheological analysis, field emission scanning electron microscopy, Fourier transform infrared spectroscopy and nuclear magnetic resonance measurements. The biological responsiveness was assessed using the MG-63 human osteoblast cell li

Chronopoulou, L., Cacciotti, I., Amalfitano, A., Di Nitto, A., D'Arienzo, V., Nocca, G., Cleofe Palocci, A., Biosynthesis of innovative calcium phosphate/hydrogel composites: physicochemical and biological characterisation, <<NANOTECHNOLOGY>>, 2021; 32 (9): N/A-N/A. [doi:10.1088/1361-6528/abc5f6] [http://hdl.handle.net/10807/164579]

Biosynthesis of innovative calcium phosphate/hydrogel composites: physicochemical and biological characterisation

Amalfitano, Adriana
Membro del Collaboration Group
;
Nocca, Giuseppina
Penultimo
Methodology
;
2021

Abstract

The goal of supporting and directing tissue regeneration requires the design of new, advanced materials, with features like biocompatibility, biodegradability and adequate mechanical properties. Our work was focused on developing a new injectable biomimetic composite material, based on a peptidic hydrogel and calcium phosphates with the aim of mimicking the chemical composition of natural bone tissue. Arg-Gly-Asp-grafted chitosan was used to promote cell adhesion. The obtained composite hydrogel was characterized with differential scanning calorimetry measurements, rheological analysis, field emission scanning electron microscopy, Fourier transform infrared spectroscopy and nuclear magnetic resonance measurements. The biological responsiveness was assessed using the MG-63 human osteoblast cell li
2021
Inglese
Chronopoulou, L., Cacciotti, I., Amalfitano, A., Di Nitto, A., D'Arienzo, V., Nocca, G., Cleofe Palocci, A., Biosynthesis of innovative calcium phosphate/hydrogel composites: physicochemical and biological characterisation, <<NANOTECHNOLOGY>>, 2021; 32 (9): N/A-N/A. [doi:10.1088/1361-6528/abc5f6] [http://hdl.handle.net/10807/164579]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/164579
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 22
social impact