We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.
Romano, A., Di Fonso, M., Mormile, F., Quaratino, D., Giuffreda, F., Venuti, A., Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report, <<ALLERGY>>, 1996; 51 (4): 269-271. [doi:10.1111/j.1398-9995.1996.tb04605.x] [http://hdl.handle.net/10807/164524]
Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report
Romano, Antonino;Mormile, Flaminio;
1996
Abstract
We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.
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