We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.

Romano, A., Di Fonso, M., Mormile, F., Quaratino, D., Giuffreda, F., Venuti, A., Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report, <<ALLERGY>>, 1996; 51 (4): 269-271. [doi:10.1111/j.1398-9995.1996.tb04605.x] [http://hdl.handle.net/10807/164524]

Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report

Romano, Antonino;Mormile, Flaminio;
1996

Abstract

We describe the case of a 20-year-old man who developed an obstructive bronchial reaction accompanied by a maculopapular facial rash 8 h after an aerosol treatment with the mucolytic drug stepronin. The results of intradermal and patch testing with stepronin, together with those of bronchial challenge and histologic findings in patch-tested skin, indicate that the patient's reaction involved an accelerated cell-mediated mechanism of hypersensitivity. Bronchial challenges with methacholine demonstrated a transient increase in nonspecific bronchial hyperreactivity.
1996
Inglese
Romano, A., Di Fonso, M., Mormile, F., Quaratino, D., Giuffreda, F., Venuti, A., Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: A case report, <<ALLERGY>>, 1996; 51 (4): 269-271. [doi:10.1111/j.1398-9995.1996.tb04605.x] [http://hdl.handle.net/10807/164524]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/164524
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? ND
social impact