Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.
Bianchi, M., Orlando, N., Valentini, C. G., Papacci, P., Vento, G., Teofili, L., Infectious complications in neonatal transfusion: Narrative review and personal contribution, <<TRANSFUSION AND APHERESIS SCIENCE>>, 2020; 59 (5): 102951-N/A. [doi:10.1016/j.transci.2020.102951] [http://hdl.handle.net/10807/164413]
Infectious complications in neonatal transfusion: Narrative review and personal contribution
Orlando, Nicoletta;Papacci, Patrizia;Vento, Giovanni;Teofili, Luciana
2020
Abstract
Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported case-reports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.