The nm23 gene, originally identified by differential hybridization between two murine melanoma cell lines endowed with different metastatic potential, has been reported to play a metastasis suppressor function in different experimentale models. Several studies have focused on the favorable clinical significance of nm23 overexpression as a metastasis suppessor marker in breast, prostate, and gastric cancer, although conflicting data have been reported. In our laboratory, the immunohistochemical expression of nm23-H1 has been Investigated in a series of 106 primary human ovarian carcinomas in order to determine its possible association with clinicopatholoigcla characteristics and epidermal growth factors receptor (EGFR).
Ferrandina, G., Scambia, G., Marone, M., Benedetti Panici, P., Giannitelli, C., Pernisco, S., Coronetta, F., Mancuso, S., NM23 in ovarian cancer: Correlation with clinicopathological and biochemical parameters, <<ANNALS OF THE NEW YORK ACADEMY OF SCIENCES>>, 1996; 784 (1 Challenges an): 509-512. [doi:10.1111/j.1749-6632.1996.tb16271.x] [http://hdl.handle.net/10807/162569]
NM23 in ovarian cancer: Correlation with clinicopathological and biochemical parameters
Ferrandina, G.;Scambia, G.;Mancuso, S.
1996
Abstract
The nm23 gene, originally identified by differential hybridization between two murine melanoma cell lines endowed with different metastatic potential, has been reported to play a metastasis suppressor function in different experimentale models. Several studies have focused on the favorable clinical significance of nm23 overexpression as a metastasis suppessor marker in breast, prostate, and gastric cancer, although conflicting data have been reported. In our laboratory, the immunohistochemical expression of nm23-H1 has been Investigated in a series of 106 primary human ovarian carcinomas in order to determine its possible association with clinicopatholoigcla characteristics and epidermal growth factors receptor (EGFR).
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
