The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.

Fazzina, G., Lazzarino, G., Tavazzi, B., Galvano, F., Galvano, G., Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside, Abstract de <<11th Biennial Meeting of the Society for Free Radical Research International.>>, (Parigi, 03-07 July 2002 ), Monduzzi, Bologna 2002: 547-550 [http://hdl.handle.net/10807/16171]

Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside

Amorini, Am;Tavazzi, Barbara;
2002

Abstract

The cyanidin-3-O--glucopyranoside (C-3-G) antioxidant effects were assessed in two models of increased oxidative stress. Isolated post-ischemic rat heart reperfused with C-3-G showed inhibition of malondialdehyde (MDA) formation (-67% and -94% in 10 and 30 M C-3-G-reperfused hearts, respectively) and improved energy metabolism. Normoxic hearts perfused in the recirculating Langendorff mode with 10 and 30 M C-3-G indicated that C-3-G can permeate within myocardial cells. Dose-dependent decrease of MDA generation by C-3-G was observed in 2 mM H2O2-treated human erythrocytes (apparent IC50 of 5.12 M and 38.43 M were calculated for C-3-G and resveratrol, respectively). In conclusion, C-3-G (largely present also in pigmented oranges) may have beneficial effects in case of increased oxidative stress.
eng
Proceeding of the 11th Biennial Meeting of the Society for Free Radical Research International.
11th Biennial Meeting of the Society for Free Radical Research International.
Parigi
3-lug-2002
7-lug-2002
Fazzina, G., Lazzarino, G., Tavazzi, B., Galvano, F., Galvano, G., Cellular protection from oxidative stress by the blood orange pigment cyanidin-3-O-beta-glucopyranoside, Abstract de <<11th Biennial Meeting of the Society for Free Radical Research International.>>, (Parigi, 03-07 July 2002 ), Monduzzi, Bologna 2002: 547-550 [http://hdl.handle.net/10807/16171]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/16171
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