The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.

Pandolfi, F., Franza, L., Carusi, V., Altamura, S., Andriollo, G., Nucera, E., Interleukin-6 in Rheumatoid Arthritis, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2020; 21 (15): 5238-N/A. [doi:10.3390/ijms21155238] [http://hdl.handle.net/10807/161301]

Interleukin-6 in Rheumatoid Arthritis

Pandolfi, Franco
Primo
;
Franza, Laura;Andriollo, Gloria;Nucera, Eleonora
Ultimo
2020

Abstract

The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
Inglese
Pandolfi, F., Franza, L., Carusi, V., Altamura, S., Andriollo, G., Nucera, E., Interleukin-6 in Rheumatoid Arthritis, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2020; 21 (15): 5238-N/A. [doi:10.3390/ijms21155238] [http://hdl.handle.net/10807/161301]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/161301
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