We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.
Sica, G., Angelucci, C., Iacopino, F., Lama, G., Robustelli Della Cuna, G., Serlupi-Crescenzi, O., Donini, S., Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells, <<ANTICANCER RESEARCH>>, 1992; 12 (6B): 2061-2064 [http://hdl.handle.net/10807/160828]
Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells
Sica, Gigliola
Primo
;Angelucci, CristianaSecondo
;Iacopino, Fortunata;Lama, Gina;
1992
Abstract
We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.
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