Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.
Giaccari, A., Sorice, G., Muscogiuri, G., Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment, <<NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES>>, 2009; 19 (5): 365-377. [doi:10.1016/j.numecd.2009.03.018] [http://hdl.handle.net/10807/16048]
Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment
Giaccari, Andrea;Sorice, Gianpio;Muscogiuri, Giovanna
2009
Abstract
Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.
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