Background-We investigated the long-term impact of different stent types and diabetes mellitus (DM) in patients undergoing percutaneous coronary intervention (PCI) of bifurcation lesions, based on a large multicenter survey endorsed by the Italian Society of Invasive Cardiology. Methods and Results-Relative benefits of drug eluting stent (DES) over bare metal stent (BMS) in patients with (n=1049) and without (n=3020) DM were analyzed with extensive multivariable adjustment. At 3 years, stenting with DES was associated with lower adjusted risk of major adverse cardiac events (MACE, adjusted hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.15 to 0.49, P<0.001), cardiac death, and target lesion revascularization in DM patients but failed to demonstrate any significant benefit in patients without DM. Conclusions-In a large observational registry with admitted potential for selection bias and residual confounding, DES in DM patients with coronary bifurcation lesions were associated with improved outcomes in terms of MACE, cardiac death, and repeat revascularization at long-term follow up. These figures were not replicated in non-DM subjects. © 2011 American Heart Association, Inc.
Capodanno, D., Tamburino, C., Sangiorgi, G. M., Romagnoli, E., Colombo, A., Burzotta, F., Gasparini, G. L., Bolognese, L., Paloscia, L., Rubino, P., Sardella, G., Briguori, C., Ettori, F., Glieca, F., Di Girolamo, D., Sheiban, I., Piatti, L., Greco, C., Petronio, A. S., Loi, B., Lyoi, E., Benassi, A., Patti, A., Gaspardone, A., De Servi, S., Impact of drug-eluting stents and diabetes mellitus in patients with coronary bifurcation lesions: A survey from the italian society of invasive cardiology, <<CIRCULATION. CARDIOVASCULAR INTERVENTIONS.>>, 2011; 4 (1): 72-79. [doi:10.1161/CIRCINTERVENTIONS.110.959460] [http://hdl.handle.net/10807/158367]
Impact of drug-eluting stents and diabetes mellitus in patients with coronary bifurcation lesions: A survey from the italian society of invasive cardiology
Romagnoli, Elisa;Burzotta, Francesco;Rubino, Pasquale;Glieca, Franco;
2011
Abstract
Background-We investigated the long-term impact of different stent types and diabetes mellitus (DM) in patients undergoing percutaneous coronary intervention (PCI) of bifurcation lesions, based on a large multicenter survey endorsed by the Italian Society of Invasive Cardiology. Methods and Results-Relative benefits of drug eluting stent (DES) over bare metal stent (BMS) in patients with (n=1049) and without (n=3020) DM were analyzed with extensive multivariable adjustment. At 3 years, stenting with DES was associated with lower adjusted risk of major adverse cardiac events (MACE, adjusted hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.15 to 0.49, P<0.001), cardiac death, and target lesion revascularization in DM patients but failed to demonstrate any significant benefit in patients without DM. Conclusions-In a large observational registry with admitted potential for selection bias and residual confounding, DES in DM patients with coronary bifurcation lesions were associated with improved outcomes in terms of MACE, cardiac death, and repeat revascularization at long-term follow up. These figures were not replicated in non-DM subjects. © 2011 American Heart Association, Inc.
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