In The Lancet Oncology, Michael Frumovitz and colleagues1 report quality-of-life outcomes of the randomised, phase 3, non-inferiority LACC trial.2 In the LACC trial, patients with early stage cervical cancer were randomly assigned (1:1) to receive open radical hysterectomy or minimally invasive surgery. At 3 years, compared with the open radical hysterectomy group, patients in the minimally invasive surgery group had worse disease-free survival (97·1% vs 91.2%; hazard ratio [HR] 3·74, 95% CI 1·63–8·58; p=0·002) and overall survival (99·0% vs 93·8%; HR 6·00, 1·77–20·30). On the basis of these results, in 2019, the National Comprehensive Cancer Network guidelines and the European Society of Gynaecological Oncology Scientific Committee recommended that the open approach should be considered the gold standard surgical approach for the treatment of early stage cervical cancer.

Ferrandina, M. G., Corrado, G., Scambia, G., Minimally invasive surgery and quality of life in cervical cancer, <<THE LANCET ONCOLOGY>>, N/A; 21 (6): 746-748-748. [doi:10.1016/S1470-2045(20)30161-3] [http://hdl.handle.net/10807/156047]

Minimally invasive surgery and quality of life in cervical cancer

Ferrandina, Maria Gabriella
Conceptualization
;
Corrado, Giacomo
Writing – Original Draft Preparation
;
Scambia, Giovanni
Conceptualization
2020

Abstract

In The Lancet Oncology, Michael Frumovitz and colleagues1 report quality-of-life outcomes of the randomised, phase 3, non-inferiority LACC trial.2 In the LACC trial, patients with early stage cervical cancer were randomly assigned (1:1) to receive open radical hysterectomy or minimally invasive surgery. At 3 years, compared with the open radical hysterectomy group, patients in the minimally invasive surgery group had worse disease-free survival (97·1% vs 91.2%; hazard ratio [HR] 3·74, 95% CI 1·63–8·58; p=0·002) and overall survival (99·0% vs 93·8%; HR 6·00, 1·77–20·30). On the basis of these results, in 2019, the National Comprehensive Cancer Network guidelines and the European Society of Gynaecological Oncology Scientific Committee recommended that the open approach should be considered the gold standard surgical approach for the treatment of early stage cervical cancer.
2020
Inglese
Ferrandina, M. G., Corrado, G., Scambia, G., Minimally invasive surgery and quality of life in cervical cancer, <<THE LANCET ONCOLOGY>>, N/A; 21 (6): 746-748-748. [doi:10.1016/S1470-2045(20)30161-3] [http://hdl.handle.net/10807/156047]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/156047
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