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EnglishBACKGROUND: Growing evidence suggests that vitamin D deficiency might be implicated in the development of active tuberculosis (TB). We evaluated vitamin D levels in children with active TB compared to children with latent TB infection (LTBI), non-TB pneumonia (NTBP) and healthy controls to determine if there was a difference. METHODS: In this prospective study, vitamin D levels were measured and compared between the four groups and adjusted for age, ethnicity, gender and season of sample collection. RESULTS: Fifty-seven children were included: 24.6% active TB, 28.1% LTBI, 22.8% NPTB and 24.6% healthy controls. 36.8% of all children tested had an insufficient or deficient vitamin D level. Vitamin D level was significantly lower in active TB compared to other groups (p = 0.004). CONCLUSIONS: Our study showed a correlation between hypovitaminosis D and active pulmonary TB.
Buonsenso, D., Sali, M., Pata, D., Masiello, E., Salerno, G., Ceccarelli, M., Delogu, G., Valentini, P., Vitamin D Levels in Active TB, Latent TB, Non-TB Pneumonia and Healthy Children: A Prospective Observational Study, <<FETAL AND PEDIATRIC PATHOLOGY>>, 2018; 37 (5): 337-347. [doi:10.1080/15513815.2018.1509407] [http://hdl.handle.net/10807/155422]
| Autori: | ||
| Titolo: | Vitamin D Levels in Active TB, Latent TB, Non-TB Pneumonia and Healthy Children: A Prospective Observational Study | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/15513815.2018.1509407 | |
| Data di pubblicazione: | 2018 | |
| Abstract: | BACKGROUND: Growing evidence suggests that vitamin D deficiency might be implicated in the development of active tuberculosis (TB). We evaluated vitamin D levels in children with active TB compared to children with latent TB infection (LTBI), non-TB pneumonia (NTBP) and healthy controls to determine if there was a difference. METHODS: In this prospective study, vitamin D levels were measured and compared between the four groups and adjusted for age, ethnicity, gender and season of sample collection. RESULTS: Fifty-seven children were included: 24.6% active TB, 28.1% LTBI, 22.8% NPTB and 24.6% healthy controls. 36.8% of all children tested had an insufficient or deficient vitamin D level. Vitamin D level was significantly lower in active TB compared to other groups (p = 0.004). CONCLUSIONS: Our study showed a correlation between hypovitaminosis D and active pulmonary TB. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Buonsenso, D., Sali, M., Pata, D., Masiello, E., Salerno, G., Ceccarelli, M., Delogu, G., Valentini, P., Vitamin D Levels in Active TB, Latent TB, Non-TB Pneumonia and Healthy Children: A Prospective Observational Study, <<FETAL AND PEDIATRIC PATHOLOGY>>, 2018; 37 (5): 337-347. [doi:10.1080/15513815.2018.1509407] [http://hdl.handle.net/10807/155422] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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