Selenium is a trace element, nutritionally classified as an essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is extensively described here. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication.

Silvestrini, A., Mordente, A., Martino, G., Bruno, C., Vergani, E., Meucci Calabrese, E., Mancini, A., The role of selenium in oxidative stress and in nonthyroidal illness syndrome (NTIS): An overview, <<CURRENT MEDICINAL CHEMISTRY>>, 2020; 27 (3): 423-449. [doi:10.2174/0929867325666180201111159] [http://hdl.handle.net/10807/154406]

The role of selenium in oxidative stress and in nonthyroidal illness syndrome (NTIS): An overview

Silvestrini, Andrea
Primo
;
Mordente, Alvaro;Bruno, Carmine;Vergani, Edoardo;Meucci Calabrese, Elisabetta;Mancini, Antonio
Ultimo
2020

Abstract

Selenium is a trace element, nutritionally classified as an essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is extensively described here. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication.
2020
Inglese
Silvestrini, A., Mordente, A., Martino, G., Bruno, C., Vergani, E., Meucci Calabrese, E., Mancini, A., The role of selenium in oxidative stress and in nonthyroidal illness syndrome (NTIS): An overview, <<CURRENT MEDICINAL CHEMISTRY>>, 2020; 27 (3): 423-449. [doi:10.2174/0929867325666180201111159] [http://hdl.handle.net/10807/154406]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/154406
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 13
social impact