Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Advancing age is a major risk factor for developing cardiovascular disease because of the lifelong exposure to cardiovascular risk factors and specific alterations affecting the heart and the vasculature during ageing. Indeed, the ageing heart is characterized by structural and functional changes that are caused by alterations in fundamental cardiomyocyte functions. In particular, the myocardium is heavily dependent on mitochondrial oxidative metabolism and is especially susceptible to mitochondrial dysfunction. Indeed, primary alterations in mitochondrial function, which are subsequently amplified by defective quality control mechanisms, are considered to be major contributing factors to cardiac senescence. In this Review, we discuss the mechanisms linking defective mitochondrial quality control mechanisms (that is, proteostasis, biogenesis, dynamics, and autophagy) to organelle dysfunction in the context of cardiac ageing. We also illustrate relevant molecular pathways that might be exploited for the prevention and treatment of age-related heart dysfunction.

Picca, A., Mankowski, R. T., Burman, J. L., Donisi, L., Kim, J. -., Marzetti, E., Leeuwenburgh, C., Mitochondrial quality control mechanisms as molecular targets in cardiac ageing, <<NATURE REVIEWS. CARDIOLOGY>>, 2018; 15 (9): 543-554. [doi:10.1038/s41569-018-0059-z] [http://hdl.handle.net/10807/154294]

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

Marzetti, Emanuele
;
2018

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Advancing age is a major risk factor for developing cardiovascular disease because of the lifelong exposure to cardiovascular risk factors and specific alterations affecting the heart and the vasculature during ageing. Indeed, the ageing heart is characterized by structural and functional changes that are caused by alterations in fundamental cardiomyocyte functions. In particular, the myocardium is heavily dependent on mitochondrial oxidative metabolism and is especially susceptible to mitochondrial dysfunction. Indeed, primary alterations in mitochondrial function, which are subsequently amplified by defective quality control mechanisms, are considered to be major contributing factors to cardiac senescence. In this Review, we discuss the mechanisms linking defective mitochondrial quality control mechanisms (that is, proteostasis, biogenesis, dynamics, and autophagy) to organelle dysfunction in the context of cardiac ageing. We also illustrate relevant molecular pathways that might be exploited for the prevention and treatment of age-related heart dysfunction.
2018
Inglese
Picca, A., Mankowski, R. T., Burman, J. L., Donisi, L., Kim, J. -., Marzetti, E., Leeuwenburgh, C., Mitochondrial quality control mechanisms as molecular targets in cardiac ageing, <<NATURE REVIEWS. CARDIOLOGY>>, 2018; 15 (9): 543-554. [doi:10.1038/s41569-018-0059-z] [http://hdl.handle.net/10807/154294]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/154294
Citazioni
  • ???jsp.display-item.citation.pmc??? 121
  • Scopus 210
  • ???jsp.display-item.citation.isi??? 196
social impact