This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.
Ercolani, C., Marchiò, C., Di Benedetto, A., Fabi, A., Perracchio, L., Vici, P., Sperati, F., Buglioni, S., Arena, V., Pescarmona, E., Sapino Irene Terrenato, A., Mottolese., M., Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification, <<JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH>>, 2017; 36 (1): 143-153. [doi:10.1186/s13046-017-0613-2] [http://hdl.handle.net/10807/153758]
Breast Carcinomas With Low Amplified/Equivocal HER2 by Ish: Potential Supporting Role of Multiplex Ligation-Dependent Probe Amplification
Arena, VincenzoMembro del Collaboration Group
;
2017
Abstract
This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) ranging between 4.0 and 5.9 by in situ hybridization.
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