Purpose: The impact of vitamin D supplementation on thyroid function is not clear and the relationship between hypovitaminosis D and autoimmune thyroiditis (ATD) incidence and evolution is still a matter of debate. The aim of this study was to retrospectively evaluate the impact of vitamin D supplementation on thyroid function in subjects with and without ATD. Methods: One hundred and ninety-eight euthyroid subjects, with diagnosis of “hypovitaminosis D” (<30 ng/mL) who had been taking supplementation therapy with cholecalciferol for different time periods, were included. They were divided in two groups according to the previous diagnosis of ATD: “ATD-neg” group including subjects without ATD [n = 103 (52%)]; “ATD-pos” group including subjects with a confirmed diagnosis of ATD [n = 95 (48%)]. For both groups, we considered TSH and 25 hydroxyvitamin D (25OHD) levels before (T0) and after (T1) cholecalciferol supplementation. We also considered the treatment duration and the monthly dose of cholecalciferol expressed as IU/month. Results: In hypovitaminosis D subjects with ATD, TSH levels significantly decreased after therapy with cholecalciferol 100.000 IU/month [mean ± SD, TSH at T0: 2.67 ± 1.21 vs. TSH at T1: 2.28 ± 0.86, p = 0.028]. No significant TSH variation was observed in ATD-neg group, irrespective of treatment dose and duration. As expected, 25OHD levels significantly improved with all monthly doses and especially in the group receiving 100.000 IU/month. Conclusions: Cholecalciferol supplementation improved thyroid function in euthyroid ATD-pos subjects affected with severe hypovitaminosis D. In particular, a significant reduction in TSH levels was observed in subjects with very low baseline 25OHD levels, after taking high monthly doses of cholecalciferol.

Villa, A., Corsello, A., Cintoni, M., Papi, G., Pontecorvi, A., Corsello, S. M., Paragliola, R. M., Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis, <<ENDOCRINE>>, 2020; (April): N/A-N/A. [doi:10.1007/s12020-020-02274-9] [http://hdl.handle.net/10807/153176]

Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis

Corsello, A.
Secondo
Writing – Original Draft Preparation
;
Papi, G.
Investigation
;
Pontecorvi, A.
Supervision
;
Corsello, S. M.
Penultimo
Writing – Review & Editing
;
Paragliola, R. M.
Ultimo
Writing – Original Draft Preparation
2020

Abstract

Purpose: The impact of vitamin D supplementation on thyroid function is not clear and the relationship between hypovitaminosis D and autoimmune thyroiditis (ATD) incidence and evolution is still a matter of debate. The aim of this study was to retrospectively evaluate the impact of vitamin D supplementation on thyroid function in subjects with and without ATD. Methods: One hundred and ninety-eight euthyroid subjects, with diagnosis of “hypovitaminosis D” (<30 ng/mL) who had been taking supplementation therapy with cholecalciferol for different time periods, were included. They were divided in two groups according to the previous diagnosis of ATD: “ATD-neg” group including subjects without ATD [n = 103 (52%)]; “ATD-pos” group including subjects with a confirmed diagnosis of ATD [n = 95 (48%)]. For both groups, we considered TSH and 25 hydroxyvitamin D (25OHD) levels before (T0) and after (T1) cholecalciferol supplementation. We also considered the treatment duration and the monthly dose of cholecalciferol expressed as IU/month. Results: In hypovitaminosis D subjects with ATD, TSH levels significantly decreased after therapy with cholecalciferol 100.000 IU/month [mean ± SD, TSH at T0: 2.67 ± 1.21 vs. TSH at T1: 2.28 ± 0.86, p = 0.028]. No significant TSH variation was observed in ATD-neg group, irrespective of treatment dose and duration. As expected, 25OHD levels significantly improved with all monthly doses and especially in the group receiving 100.000 IU/month. Conclusions: Cholecalciferol supplementation improved thyroid function in euthyroid ATD-pos subjects affected with severe hypovitaminosis D. In particular, a significant reduction in TSH levels was observed in subjects with very low baseline 25OHD levels, after taking high monthly doses of cholecalciferol.
Inglese
Villa, A., Corsello, A., Cintoni, M., Papi, G., Pontecorvi, A., Corsello, S. M., Paragliola, R. M., Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis, <<ENDOCRINE>>, 2020; (April): N/A-N/A. [doi:10.1007/s12020-020-02274-9] [http://hdl.handle.net/10807/153176]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/153176
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