We report two clinical cases of cardiac arrest, the former due to an adverse effect of intravenous (i.v.) propranolol in a patient with systemic sclerosis, the latter from a propranolol suicidal overdose. In both cases, conventional advanced life support (ALS) was ineffective but both patients eventually responded to the administration of enoximone, a phosphodiesterase III (PDE III) inhibitor. After the arrest, both patients regained consciousness and were discharged home. The chronotropic and inotropic effects of PDE III inhibitors are due to inhibition of intracellular PDEIII and are therefore unaffected by betablockers. These cases suggest that PDEIII inhibitors may be useful in restoring spontaneous circulation in cardiac arrest associated with beta-blocker administration when standard ALS is ineffective. © 2006 The Authors Journal compilation © 2006 Acta Anaesthesiol Scand.

Sandroni, C., Cavallaro, F., Caricato, A., Scapigliati, A., Fenici, P., Antonelli, M., Enoximone in cardiac arrest caused by propranolol: Two case reports, <<ACTA ANAESTHESIOLOGICA SCANDINAVICA>>, 2006; 50 (6): 759-761. [doi:10.1111/j.1399-6576.2006.01026.x] [http://hdl.handle.net/10807/152749]

Enoximone in cardiac arrest caused by propranolol: Two case reports

Sandroni, Claudio
Primo
Writing – Original Draft Preparation
;
Cavallaro, Fabio
Secondo
Writing – Original Draft Preparation
;
Caricato, Anselmo
Data Curation
;
Scapigliati, Andrea
Writing – Review & Editing
;
Fenici, Peter
Writing – Review & Editing
;
Antonelli, Massimo
Ultimo
Supervision
2006

Abstract

We report two clinical cases of cardiac arrest, the former due to an adverse effect of intravenous (i.v.) propranolol in a patient with systemic sclerosis, the latter from a propranolol suicidal overdose. In both cases, conventional advanced life support (ALS) was ineffective but both patients eventually responded to the administration of enoximone, a phosphodiesterase III (PDE III) inhibitor. After the arrest, both patients regained consciousness and were discharged home. The chronotropic and inotropic effects of PDE III inhibitors are due to inhibition of intracellular PDEIII and are therefore unaffected by betablockers. These cases suggest that PDEIII inhibitors may be useful in restoring spontaneous circulation in cardiac arrest associated with beta-blocker administration when standard ALS is ineffective. © 2006 The Authors Journal compilation © 2006 Acta Anaesthesiol Scand.
2006
Inglese
Sandroni, C., Cavallaro, F., Caricato, A., Scapigliati, A., Fenici, P., Antonelli, M., Enoximone in cardiac arrest caused by propranolol: Two case reports, <<ACTA ANAESTHESIOLOGICA SCANDINAVICA>>, 2006; 50 (6): 759-761. [doi:10.1111/j.1399-6576.2006.01026.x] [http://hdl.handle.net/10807/152749]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/152749
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