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EnglishMatrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.
Loreto, C., Filetti, V., Eduardo Almeida, L., Rita Maria La Rosa, G., Leonardi, R., Grippaudo, C., Lo Giudice, A., MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction, <<EUROPEAN JOURNAL OF HISTOCHEMISTRY>>, 2020; 2020 (64:3113): 8-12 [http://hdl.handle.net/10807/151171]
| Autori: | ||
| Titolo: | MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction | |
| Data di pubblicazione: | 2020 | |
| Abstract: | Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Loreto, C., Filetti, V., Eduardo Almeida, L., Rita Maria La Rosa, G., Leonardi, R., Grippaudo, C., Lo Giudice, A., MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction, <<EUROPEAN JOURNAL OF HISTOCHEMISTRY>>, 2020; 2020 (64:3113): 8-12 [http://hdl.handle.net/10807/151171] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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