Because of its peculiar characteristics, hair analysis provides a way of obtaining information that cannot be acquired by other commonly used forensic medical analyses, such as blood or urine analysis. In the keratin matrix many xenobiotics are incorporated permanently, in contrast to the situation with blood or urine where they are generally only detectable for a few hours or days. Therefore hair analysis should be the method of choice in the clinical and forensic toxicology field when the assessment of repeated or chronic exposure to a drug is required, e.g. in the case of criminal responsibility, revocation/restoration of a driving licence or in workplace testing. Some factors that can affect the concentrations of drugs in hair, such as passive contamination, age, ethnicity and cosmetic treatment, must be considered. Analytical methodology is also very important: GC/MS/MS has proved to be a highly sensitive and specific technique for the detection of very low concentrations of such drugs in hair. In this study five cases of the application of hair analyses using this technique for the determination of abused drugs (opiates, cocaine, amphetamine, anabolic steroids) are described.
Gambelunghe, C., Rossi, R., Ferranti, C., Rossi, R., Bacci, M., Hair analysis by GC/MS/MS to verify abuse of drugs, <<JOURNAL OF APPLIED TOXICOLOGY>>, 2005; (Gennaio): 205-211 [http://hdl.handle.net/10807/14864]
Hair analysis by GC/MS/MS to verify abuse of drugs
Rossi, Riccardo;
2005
Abstract
Because of its peculiar characteristics, hair analysis provides a way of obtaining information that cannot be acquired by other commonly used forensic medical analyses, such as blood or urine analysis. In the keratin matrix many xenobiotics are incorporated permanently, in contrast to the situation with blood or urine where they are generally only detectable for a few hours or days. Therefore hair analysis should be the method of choice in the clinical and forensic toxicology field when the assessment of repeated or chronic exposure to a drug is required, e.g. in the case of criminal responsibility, revocation/restoration of a driving licence or in workplace testing. Some factors that can affect the concentrations of drugs in hair, such as passive contamination, age, ethnicity and cosmetic treatment, must be considered. Analytical methodology is also very important: GC/MS/MS has proved to be a highly sensitive and specific technique for the detection of very low concentrations of such drugs in hair. In this study five cases of the application of hair analyses using this technique for the determination of abused drugs (opiates, cocaine, amphetamine, anabolic steroids) are described.Campo DC | Valore | Lingua |
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dc.authority.academicField2000 | Settore MED/43 - MEDICINA LEGALE | it |
dc.authority.ancejournal | JOURNAL OF APPLIED TOXICOLOGY | en |
dc.authority.erc2011 | Toxicology | it |
dc.authority.people | Gambelunghe, C | - |
dc.authority.people | Rossi, Riccardo | it |
dc.authority.people | Ferranti, C | - |
dc.authority.people | Rossi, R | - |
dc.authority.people | Bacci, M. | - |
dc.cilea.flagannuariono | 16062 | - |
dc.cilea.flagppdsi | 16062 | - |
dc.cilea.standby | Notification sent at Mon Jun 25 17:23:22 CEST 2012, release date is 2012-06-30 | - |
dc.collection.id.s | e309db74-00b3-0599-e053-3705fe0a55db | * |
dc.collection.name | Articolo in rivista, Nota a sentenza | * |
dc.contributor.appartenenza | ROMA - Dipartimento di Sicurezza e Bioetica | * |
dc.contributor.appartenenza.mi | 33189 | * |
dc.contributor.faculty | FACOLTA' DI MEDICINA E CHIRURGIA "A.GEMELLI" | * |
dc.date.accessioned | 2012-07-02T17:42:52Z | - |
dc.date.available | 2012-07-02T17:42:52Z | - |
dc.date.issued | 2005 | - |
dc.description.abstracteng | Because of its peculiar characteristics, hair analysis provides a way of obtaining information that cannot be acquired by other commonly used forensic medical analyses, such as blood or urine analysis. In the keratin matrix many xenobiotics are incorporated permanently, in contrast to the situation with blood or urine where they are generally only detectable for a few hours or days. Therefore hair analysis should be the method of choice in the clinical and forensic toxicology field when the assessment of repeated or chronic exposure to a drug is required, e.g. in the case of criminal responsibility, revocation/restoration of a driving licence or in workplace testing. Some factors that can affect the concentrations of drugs in hair, such as passive contamination, age, ethnicity and cosmetic treatment, must be considered. Analytical methodology is also very important: GC/MS/MS has proved to be a highly sensitive and specific technique for the detection of very low concentrations of such drugs in hair. In this study five cases of the application of hair analyses using this technique for the determination of abused drugs (opiates, cocaine, amphetamine, anabolic steroids) are described. | - |
dc.description.allpeople | Gambelunghe, C; Rossi, Riccardo; Ferranti, C; Rossi, R; Bacci, M. | - |
dc.description.allpeopleoriginal | Gambelunghe, C; Rossi, Riccardo; Ferranti, C; Rossi, R; Bacci, M | it |
dc.description.fulltext | none | en |
dc.description.fulltextoriginal | none | en |
dc.description.languageisokeywords | eng | it |
dc.description.numberofauthors | 5 | - |
dc.identifier.citation | Gambelunghe, C., Rossi, R., Ferranti, C., Rossi, R., Bacci, M., Hair analysis by GC/MS/MS to verify abuse of drugs, <<JOURNAL OF APPLIED TOXICOLOGY>>, 2005; (Gennaio): 205-211 [http://hdl.handle.net/10807/14864] | it |
dc.identifier.uri | http://hdl.handle.net/10807/14864 | - |
dc.language.iso | eng | it |
dc.relation.firstpage | 205 | it |
dc.relation.issue | Gennaio | it |
dc.relation.issueyear | 2005 | it |
dc.relation.lastpage | 211 | it |
dc.relation.numberofpages | 7 | it |
dc.subject.keywords | hair analysis | it |
dc.subject.keywords | keratin | it |
dc.subject.keywords | drugs of abuse | it |
dc.subject.keywords | cocaine | it |
dc.subject.keywords | opiates | it |
dc.subject.keywords | cannabinoids | it |
dc.subject.singlekeyword | hair analysis | * |
dc.title | Hair analysis by GC/MS/MS to verify abuse of drugs | it |
dc.type | art_per_29 | - |
dc.type.contribution | Articolo su rivista scientifica / specializzata | it |
dc.type.driver | info:eu-repo/semantics/article | - |
dc.type.full | 03. Contributo in rivista::Articolo in rivista, Nota a sentenza | it |
dc.type.genius | Pubblicazione su rivista con Impact Factor | - |
dc.type.miur | 262 | en |
dc.type.miurarticle | Articolo in rivista | it |
dc.type.research | AREA06 - SCIENZE MEDICHE | - |
Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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