Biological drugs, such as proteins and immunogens, are increasingly used to treat various diseases, including tumors and autoimmune diseases, and biological molecules have almost completely replaced synthetic drugs in rheumatology. Although biological treatments such as anti-tumor necrosis factor (TNF) drugs seem to be quite safe, they cause some undesirable effects, such as the onset of infections due to weakening of the immune system. Given the biological nature of these drugs, they might be recognized as extraneous; this would induce an immune reaction that neutralizes their effectiveness or lead to more serious consequences. Laboratories play a pivotal role in appropriate therapeutic management. The aim of this review was to underline the production of anti-drug antibodies during treatment with biological drugs and highlight the role of laboratories in ensuring appropriate use of these drugs.

Benucci, M., Grossi, V., Manfredi, M., Damiani, A., Infantino, M., Moscato, P., Cinquanta, L., Gremese, E., Tolusso, B., Petricca, L., Fedele, A. L., Alivernini, S., Atzeni, F., Minisola, G., Verna, R., Laboratory Monitoring of Biological Therapies in Rheumatology: The Role of Immunogenicity, <<ANNALS OF LABORATORY MEDICINE>>, 2019; 40 (2): 101-113. [doi:10.3343/alm.2020.40.2.101] [http://hdl.handle.net/10807/148284]

Laboratory Monitoring of Biological Therapies in Rheumatology: The Role of Immunogenicity

Gremese, Elisa;Tolusso, Barbara;Alivernini, Stefano;
2020

Abstract

Biological drugs, such as proteins and immunogens, are increasingly used to treat various diseases, including tumors and autoimmune diseases, and biological molecules have almost completely replaced synthetic drugs in rheumatology. Although biological treatments such as anti-tumor necrosis factor (TNF) drugs seem to be quite safe, they cause some undesirable effects, such as the onset of infections due to weakening of the immune system. Given the biological nature of these drugs, they might be recognized as extraneous; this would induce an immune reaction that neutralizes their effectiveness or lead to more serious consequences. Laboratories play a pivotal role in appropriate therapeutic management. The aim of this review was to underline the production of anti-drug antibodies during treatment with biological drugs and highlight the role of laboratories in ensuring appropriate use of these drugs.
2020
Inglese
Benucci, M., Grossi, V., Manfredi, M., Damiani, A., Infantino, M., Moscato, P., Cinquanta, L., Gremese, E., Tolusso, B., Petricca, L., Fedele, A. L., Alivernini, S., Atzeni, F., Minisola, G., Verna, R., Laboratory Monitoring of Biological Therapies in Rheumatology: The Role of Immunogenicity, <<ANNALS OF LABORATORY MEDICINE>>, 2019; 40 (2): 101-113. [doi:10.3343/alm.2020.40.2.101] [http://hdl.handle.net/10807/148284]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/148284
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