The genetic variant A1 of bovine β-casein (β-Cn) presents a His residue at a position 67 of the mature protein. This feature makes the Ile66-His67 bond more vulnerable to enzymatic cleavage, determining the release of the peptide β-Cn f(60–66), named β-casomorphin 7 (BCM7). BCM7 is an opioid-agonist for μ receptors, and it has been hypothesized to be involved in the development of different non-transmissible diseases in humans. In the last decade, studies have provided additional results on the potential health impact of β-Cn A1 and BCM7. These studies, here reviewed, highlighted a relation between the consumption of β-Cn A1 (and its derivative BCM7) and the increase of inflammatory response as well as discomfort at the gastrointestinal level. Conversely, the role of BCM7 and the effects of ingestion of β-Cn A1 on the onset or worsening of other non-transmissible diseases as caused or favored by still need proof of evidence. Overall, the reviewed literature demonstrates that the “β-Cn A1/BCM7 issue” remains an intriguing but not exhaustively explained topic in human nutrition. On this basis, policies in favor of breeding for β-Cn variants not releasing BCM7 and consumption of “A1-like” milk appear not yet sound for a healthier and safer nutrition.

Summer, A., Di Frangia, F., Ajmone Marsan, P., De Noni, I., Malacarne, M., Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns, <<CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION>>, 2020; (N/A): 1-19-19. [doi:10.1080/10408398.2019.1707157] [http://hdl.handle.net/10807/146047]

Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns

Ajmone Marsan, P.;
2020

Abstract

The genetic variant A1 of bovine β-casein (β-Cn) presents a His residue at a position 67 of the mature protein. This feature makes the Ile66-His67 bond more vulnerable to enzymatic cleavage, determining the release of the peptide β-Cn f(60–66), named β-casomorphin 7 (BCM7). BCM7 is an opioid-agonist for μ receptors, and it has been hypothesized to be involved in the development of different non-transmissible diseases in humans. In the last decade, studies have provided additional results on the potential health impact of β-Cn A1 and BCM7. These studies, here reviewed, highlighted a relation between the consumption of β-Cn A1 (and its derivative BCM7) and the increase of inflammatory response as well as discomfort at the gastrointestinal level. Conversely, the role of BCM7 and the effects of ingestion of β-Cn A1 on the onset or worsening of other non-transmissible diseases as caused or favored by still need proof of evidence. Overall, the reviewed literature demonstrates that the “β-Cn A1/BCM7 issue” remains an intriguing but not exhaustively explained topic in human nutrition. On this basis, policies in favor of breeding for β-Cn variants not releasing BCM7 and consumption of “A1-like” milk appear not yet sound for a healthier and safer nutrition.
Inglese
Summer, A., Di Frangia, F., Ajmone Marsan, P., De Noni, I., Malacarne, M., Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns, <<CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION>>, 2020; (N/A): 1-19-19. [doi:10.1080/10408398.2019.1707157] [http://hdl.handle.net/10807/146047]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/146047
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