A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

Bugli, F., Manzara, S., Torelli, R., Graffeo, R., Santangelo, R., Cattani, P., Fadda, G., Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis, <<JOURNAL OF CLINICAL MICROBIOLOGY>>, 2004; (42 (3)): 1250-1253 [http://hdl.handle.net/10807/14458]

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Bugli, Francesca;Manzara, Stefania;Torelli, Riccardo;Graffeo, Rosalia;Santangelo, Rosaria;Cattani, Paola;Fadda, Giovanni
2004

Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.
Inglese
Bugli, F., Manzara, S., Torelli, R., Graffeo, R., Santangelo, R., Cattani, P., Fadda, G., Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis, <>, 2004; (42 (3)): 1250-1253 [http://hdl.handle.net/10807/14458]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/14458
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