A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

Bugli, F., Manzara, S., Torelli, R., Graffeo, R., Santangelo, R., Cattani, P., Fadda, G., Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis, <<JOURNAL OF CLINICAL MICROBIOLOGY>>, 2004; (42 (3)): 1250-1253 [http://hdl.handle.net/10807/14458]

Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis

Bugli, Francesca;Manzara, Stefania;Torelli, Riccardo;Graffeo, Rosalia;Santangelo, Rosaria;Cattani, Paola;Fadda, Giovanni
2004

Abstract

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.
2004
Inglese
Bugli, F., Manzara, S., Torelli, R., Graffeo, R., Santangelo, R., Cattani, P., Fadda, G., Human monoclonal antibody fragment specific for glycoprotein G in Herpes simplex type 2 with applications for serotype-specific diagnosis, <<JOURNAL OF CLINICAL MICROBIOLOGY>>, 2004; (42 (3)): 1250-1253 [http://hdl.handle.net/10807/14458]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/14458
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