Far from being an accidental evolutional step, the fusion of a channel pore with a kinase domain within the TRPM7 molecule represents an optimized and integrated unit, able to couple extracellular sensing to intracellular signalling. The article by Rios et al. strongly implicates both TRPM7 kinase and Mg2+ homeostasis in cardiovascular health, but before these findings may achieve translational relevance, it is imperative to dissect all the underlying molecular mysteries.
Trapani, V., Wolf Minotti, F., The TRPM7 channel kinase: rekindling an old flame or not?, <<CARDIOVASCULAR RESEARCH>>, 2020; (116): 476-478. [doi:10.1093/cvr/cvz229] [https://hdl.handle.net/10807/142630]
The TRPM7 channel kinase: rekindling an old flame or not?
Trapani, ValentinaPrimo
;Wolf Minotti, FedericaUltimo
2019
Abstract
Far from being an accidental evolutional step, the fusion of a channel pore with a kinase domain within the TRPM7 molecule represents an optimized and integrated unit, able to couple extracellular sensing to intracellular signalling. The article by Rios et al. strongly implicates both TRPM7 kinase and Mg2+ homeostasis in cardiovascular health, but before these findings may achieve translational relevance, it is imperative to dissect all the underlying molecular mysteries.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
