Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.

Trapani, V., Wolf Minotti, F., Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks, <<CELL CALCIUM>>, 2019; (83): 102078-N/A. [doi:10.1016/j.ceca.2019.102078] [http://hdl.handle.net/10807/142628]

Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks

Trapani, Valentina
Primo
;
Wolf Minotti, Federica
Ultimo
2019

Abstract

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg2+ channels and other Mg2+ homeostatic factors may affect many hallmarks of cancer. The seminal idea of magnesium as a key regulator of cell proliferation has been enriched by novel intriguing findings that link magnesium and Mg2+ transporters to distinctive and complementary capabilities that enable tumour growth and metastatic dissemination. In this review, we examine the evidence on the involvement of members from the TRPM, CNNM and SCL41 protein families in cancer progression, and discuss their potential as therapeutic targets.
2019
Inglese
Trapani, V., Wolf Minotti, F., Dysregulation of Mg2+ homeostasis contributes to acquisition of cancer hallmarks, <<CELL CALCIUM>>, 2019; (83): 102078-N/A. [doi:10.1016/j.ceca.2019.102078] [http://hdl.handle.net/10807/142628]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/142628
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