CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL
D'Arena, G., Valvano, L., Vitale, C., Coscia, M., Statuto, T., Bellesi, S., Lamorte, D., Musto, P., Laurenti, L., D'Auria, F., CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results, <<LEUKEMIA RESEARCH>>, 2019; 83 (aug): 106169-N/A. [doi:10.1016/j.leukres.2019.106169] [http://hdl.handle.net/10807/142506]
CD200 and prognosis in chronic lymphocytic leukemia: Conflicting results
Vitale, Celeste;Bellesi, Silvia;Laurenti, Luca;
2019
Abstract
CD200 is a transmembrane type Ia glycoprotein belonging to theimmunoglobulin superfamily [1].It isexpressed byvariouscell types,such as B cells, a subset of T cells including activated T cells, thymo-cytes, endothelial cells, and neurons. CD200 surface expression hasbeenshowntohavearelevantroleinthedifferentialdiagnosisofB-cellchronic lymphoproliferative disorders (B-CLPDs) [2]. The major con-tributionofCD200istheabilitytodiscriminatebetweenchroniclym-phocytic leukemia (CLL) and mantle cell lymphoma (MCL), and be-tweenhairycellleukemiaanditsvariantform[3].Furthermore,ithasbeenalsodemonstratedaroleofCD200inthedifferentialdiagnosisofother forms of B-CLPDs, when incorporated in panels including othersurface markers [4,5]. However, little is known about the prognosticsignificanceofCD200expressioninCLL
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