Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.
Comoglio, P. M., Tamagnone, L., Giordano, S., Invasive growth: A two-way street for semaphorin signalling, <<NATURE CELL BIOLOGY>>, 2004; 6 (12): 1155-1157. [doi:10.1038/ncb1204-1155] [http://hdl.handle.net/10807/141388]
Invasive growth: A two-way street for semaphorin signalling
Tamagnone, Luca;
2004
Abstract
Growing evidence suggests that semaphorins - known to provide directional cues during axon guidance - also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.
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