The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
Seripa, D., Matera, M. G., D'Andrea, R. P., Gravina, C., Masullo, C., Daniele, A., Bizzarro, A., Rinaldi, M., Antuono, P., Wekstein, D. R., Dal Forno, G., Fazio, V. M., Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism, <<NEUROLOGY>>, 2004; 62 (9): 1631-1633. [doi:10.1212/01.WNL.0000125693.59817.31] [http://hdl.handle.net/10807/140910]
Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism
Masullo, Carlo;Daniele, Antonio;Bizzarro, Alessandra;Fazio, Vito Michele
2004
Abstract
The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
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