BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients. METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV. RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis. CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.

Biscetti, F., Nardella, E., Bonadia, N., Angelini, F., Pitocco, D., Santoliquido, A., Filipponi, M., Landolfi, R., Flex, A., Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease., <<CARDIOVASCULAR DIABETOLOGY>>, 2019; 2019 (18): 74-74. [doi:10.1186/s12933-019-0880-7] [http://hdl.handle.net/10807/139870]

Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease.

Biscetti F
Primo
;
Nardella E
Secondo
;
Pitocco D;Santoliquido A;Landolfi R
Penultimo
;
Flex A
Ultimo
2019

Abstract

BACKGROUND: Type-2 diabetes mellitus is one of the major risk factors of atherosclerosis, particularly in peripheral artery disease (PAD). Several studies have documented a correlation between omentin-1 serum levels, atherosclerosis, and cardiovascular diseases. However, a clear link between circulating omentin-1 and PAD in diabetic patients has yet to be established. The aim of this study was to investigate the potential role of omentin-1 in PAD in type-2 diabetic patients. METHODS: In this cross-sectional study, we analyzed omentin-1 serum levels by ELISA in 600 type-2 diabetic patients with (n = 300) and without (n = 300) PAD at Fontaine's stage II, III, or IV. RESULTS: We found that omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls (29.46 vs 49.24 ng/mL, P < 0.001) and that the levels gradually decreased in proportion to disease severity (P < 0.05). The association between omentin-1 levels and PAD remained significant after adjusting for major risk factors in a multivariate analysis. CONCLUSIONS: Our results suggest that omentin-1 is reduced in type 2 diabetic patients with PAD and that omentin-1 levels are related to disease severity.
Inglese
Biscetti, F., Nardella, E., Bonadia, N., Angelini, F., Pitocco, D., Santoliquido, A., Filipponi, M., Landolfi, R., Flex, A., Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease., <>, 2019; 2019 (18): 74-74. [doi:10.1186/s12933-019-0880-7] [http://hdl.handle.net/10807/139870]
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